BioChem - DOS

Selective Activation of C-H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis

Angewandte Chemie. international edition

Zhang, Wuyuan; Burek, Bastien O.; Ferná ndez‐ Fueyo, Elena; Alcalde, Miguel; Bloh, Jonathan Z.; Hollmann, Frank

<P><B>Abstract</B></P><P>Selective oxyfunctionalizations of inert C&#x2212;H bonds can be achieved under mild conditions by using peroxygenases. This approach, however, suffers from the poor robustness of these enzymes in the presence of hydrogen peroxide as the stoichiometric oxidant. Herein, we demonstrate that inorganic photocatalysts such as gold&#x2013;titanium dioxide efficiently provide H<SUB>2</SUB>O<SUB>2</SUB> through the methanol&#x2010;driven reductive activation of ambient oxygen in amounts that ensure that the enzyme remains highly active and stable. Using this approach, the stereoselective hydroxylation of ethylbenzene to (<I>R</I>)&#x2010;1&#x2010;phenylethanol was achieved with high enantioselectivity (>98 % <I>ee</I>) and excellent turnover numbers for the biocatalyst (>71 000).</P>

2017

John Wiley and Sons Inc.

1433-7851

1521-3773

56

48

pp.15451-15455

10.1002/anie.201708668

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART79141181