BioChem - DOS

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

Green chemistry : an international journal and green chemistry resource : GC

Wan, Lei; Heath, Rachel S.; Siritanaratkul, Bhavin; Megarity, Clare F.; Sills, Adam J.; ThompsonCurrent address: EnginZyme AB, Teknikringen 38 A, 114 28 Stockholm, Sweden., Matthew P.; Turner, Nicholas J.; Armstrong, Fraser A.

<P>Enantioselective conversion of alcohols to ketones using air as the oxidant is achieved with high rates and efficiency using an indium tin oxide (ITO) electrode in which an alcohol dehydrogenase and a photosynthetic NADPH recycling enzyme are confined within nanopores. The massive catalytic enhancement arising from nanoconfinement is exploited in an air-driven electrochemical cell, which requires no complicating control features yet allows continuous monitoring of the reaction <I>via</I> the current that flows between anode (ITO: organic chemistry) and cathode (Pt: O<SUB>2</SUB> from air).</P><P>Graphic Abstract</P><P>Enantioselective conversion of alcohols to ketones using air as the oxidant is achieved with high rates and efficiency using an indium tin oxide electrode in which an alcohol dehydrogenase and a NADPH recycling enzyme are confined within nanopores.<BR/><IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c9gc01534e'/><BR/></P>

2019

The Royal Society of Chemistry

cc-by

1463-9262

1463-9270

21

18

pp.4958-4963

10.1039/c9gc01534e

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART105417000

https://pubs.rsc.org/en/content/articlepdf/2019/gc/c9gc01534e