초록
<P><B>Abstract</B></P> <P>Carbon dioxide, CO<SUB>2</SUB> reduction and utilization for organic compounds synthesis are the potential technologies in environmental science and technology. In order to establish efficient CO<SUB>2</SUB> utilization technologies, an effective catalyst for CO<SUB>2</SUB> reduction and utilization is necessary. Among various catalysts, the biocatalyst is one of promising catalysts because it has excellent selectivity for the reaction and substrate. In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing CO<SUB>2</SUB> reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO<SUB>2</SUB> reduction with FDH are outlined. A genetic engineering modified FDH and FDH immobilized various support for improving CO<SUB>2</SUB> reduction catalytic activity also are introduced. Moreover, chemical and electrochemical system of CO<SUB>2</SUB> reduction to formic acid with FDH, aqueous homogenous system of visible-light driven CO<SUB>2</SUB> reduction to formic acid with FDH and device for visible-light driven CO<SUB>2</SUB> reduction to formic acid with FDH are also introduced as an application of FDH.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Active site and catalytic mechanism of various formate dehydrogenase are mentioned. </LI> <LI> Genetic modification to improve formate dehydrogenase performance for CO<SUB>2</SUB> reduction are introduced. </LI> <LI> CO<SUB>2</SUB> reduction systems with stabilized formate dehydrogenase immobilized various support are introduced. </LI> <LI> Chemical and electrochemical CO<SUB>2</SUB> reduction with formate dehydrogenase are mentioned. </LI> <LI> Visible-light driven CO<SUB>2</SUB> reduction systems with formate dehydrogenase are reviewed. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>