BioChem - DOS

Improving the productivity of propionic acid with FBB-immobilized cells of an adapted acid-tolerant Propionibacterium acidipropionici

Bioresource technology : biomass, bioenergy, biowastes, conversion technologies, biotransformations, production technologies

Zhu, Linqi; Wei, Peilian; Cai, Jin; Zhu, Xiangcheng; Wang, Zimeng; Huang, Lei; Xu, Zhinan

<P><B>Highlights</B></P><P>&#x025BA; <I>P. acidipropionici</I> CGMCC 1.2230 strain was selected to produce propionic acid. &#x025BA; The productivity of propionic acid was greatly improved to 0.96g/(Lh) in FBB. &#x025BA; Sugarcane bagasse hydrolysate could support the high production of propionic acid.</P> <P><B>Abstract</B></P><P>Propionic acid is an important short-chain fatty acid with many applications, but its large-scale bioproduction was hindered by the low productivity. An adapted acid-tolerant <I>Propionibacterium acidipropionici</I> CGMCC 1.2230 strain was selected to produce propionic acid with a relatively high productivity (0.29g/(Lh)) in the free-cell fermentation. Further immobilized-cell fermentation in fibrous-bed bioreactor (FBB) supported high-level repeated batch fermentations with a high productivity of 0.96g/(Lh). The FBB also presents the potential to increase final propionic acid concentration by using glucose feeding strategy. The propionic acid concentration was increased to 51.2g/L in the fed-batch fermentation with the productivity of 0.71g/(Lh). By adopting the above strategies, sugarcane bagasse hydrolysate could support the production of propionic acid with high productivity in the repeat-batch and fed-batch fermentations. The present work would pave one road to the accomplishment of large-scale bioproduction of propionic acid from renewable resources.</P>

2012

0960-8524

112

pp.248-253

10.1016/j.biortech.2012.01.055

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART62196072

Propionic acid; Productivity; Fibrous-bed bioreactor; Propionibacterium acidipropionici