BioChem - DOS

Influence of glucose fermentation on CO2 assimilation to acetate in homoacetogen Blautia coccoides GA-1

Journal of industrial microbiology & biotechnology

Liu, Chong; Li, Jianzheng; Zhang, Yupeng; Philip, Antwi; Shi, En; Chi, Xue; Meng, Jia

<P><B>Abstract</B><P>Fermentation of glucose influences CO2 assimilation to acetate in homoacetogens. Blautia coccoides was investigated for a better understanding of the metabolic characteristics of homoacetogens in mixotrophic cultures. Batch cultures of the strain with H2/CO2 as a sole carbon source reached an acetate yield of 5.32 g/g dry cell weight after 240 h of incubation. Autotrophic metabolism was inhibited as glucose was added into the culture: the higher the glucose concentration the lower the autotrophic ability of the bacterium. Autotrophy was inhibited by high glucose concentration, probably due to the competition for coenzyme A between the Embden-Meyerhof-Parnas pathway and the Wood-Ljungdahl carbon fixation pathway, the energy (adenosine triphosphate) allocation for synthesis of cell carbon and reduction of CO2, in combination with the low pH caused by the accumulation of acetate.</P></P>

2015

Oxford University Press

1367-5435

1476-5535

42

9

pp.1217-1224

10.1007/s10295-015-1646-1

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