BioChem - DOS

A synthetic biochemistry module for production of bio-based chemicals from glucose

Nature chemical biology

Opgenorth, Paul H; Korman, Tyler P; Bowie, James U

Synthetic biochemistry, the cell-free production of biologically based chemicals, is a potentially high-yield, flexible alternative to in vivo metabolic engineering. To limit costs, cell-free systems must be designed to operate continuously with minimal addition of feedstock chemicals. We describe a robust, efficient synthetic glucose breakdown pathway and implement it for the production of bioplastic. The system's performance suggests that synthetic biochemistry has the potential to become a viable industrial alternative.

2016

Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

1552-4450

1552-4469

12

6

pp.393-395

10.1038/nchembio.2062

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