BioChem - DOS

Development of the Travelling Wave Bioreactor. Part II: Engineering Characteristics and Cultivation Results

Chemie-Ingenieur-Technik

Kaiser, Stephan C.; Perepelitsa, Nadezda; Kraume, Matthias; Eibl, Dieter

<P><B>Abstract</B></P><P>The innovative travelling wave bioreactor (TWB), an orbitally shaken system, developed specifically for cell culture applications, is investigated. In this study, engineering parameters covering power input, mixing time and oxygen mass transfer obtained in two TWB prototypes are presented for the first time. Based on the results, cultivation parameters for CHO suspension cell cultivations were defined. Cell growth and substrate consumption were comparable with a wave&#8208;mixed reference bioreactor, which demonstrates the bioreactor's applicability for cultivations of mammalian cell cultures for the first time.</P>

2016

WILEY&#x2010;VCH Verlag

0009-286x

1522-2640

88

1

pp.86-92

10.1002/cite.201500091

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART74849356

CHO cultivations; Mixing time; Oxygen mass transfer; Power input; Single&#x2010; use bioreactor; Travelling wave;