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Heterologous expression of Aspergillus aculeatus endo-polygalacturonase in Pichia pastoris by high cell density fermentation and its application in textile scouring

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논문

Heterologous expression of Aspergillus aculeatus endo-polygalacturonase in Pichia pastoris by high cell density fermentation and its application in textile scouring

학술지

BMC biotechnology

저자명

Abdulrachman, Dede; Thongkred, Paweena; Kocharin, Kanokarn; Nakpathom, Monthon; Somboon, Buppha; Narumol, Nootsara; Champreda, Verawat; Eurwilaichitr, Lily; Suwanto, Antonius; Nimchua, Thidarat; Chantasingh, Duriya

초록

<P><B>Background</B></P><P>Removal of non-cellulosic impurities from cotton fabric, known as scouring, by conventional alkaline treatment causes environmental problems and reduces physical strength of fabrics. In this study, an endo-polygalacturonase (EndoPG) from <I>Aspergillus aculeatus</I> produced in <I>Pichia pastoris</I> was evaluated for its efficiency as a bioscouring agent while most current bioscouring process has been performed using crude pectinase preparation.</P><P><B>Results</B></P><P>The recombinant EndoPG exhibited a specific activity of 1892.08 U/mg on citrus pectin under the optimal condition at 50&nbsp;°C, pH&nbsp;5.0 with a V<SUB><I>max</I></SUB> and K<SUB><I>m</I></SUB> of 65,451.35&nbsp;&mu;mol/min/mL and 15.14&nbsp;mg/mL, respectively. A maximal activity of 2408.70 ± 26.50 U/mL in the culture supernatant was obtained by high cell density batch fermentation, equivalent to a 4.8 times greater yield than that from shake-flask culture. The recombinant enzyme was shown to be suitable for application as a bioscouring agent, in which the wettability of cotton fabric was increased by treatment with enzyme at 300 U/mL scouring solution at 40&nbsp;°C, pH&nbsp;5.0 for 1&nbsp;h. The bio-scoured fabric has comparable wettability to that obtained by conventional chemical scouring, but has higher tensile strength.</P><P><B>Conclusion</B></P><P>The work has demonstrated for the first time functions of <I>A. aculeatus</I> EndoPG on bioscouring in eco-textile processing. EndoPG alone was shown to possess effective scouring activity. High expression level and homogeneity could be achieved in bench-scale bioreactor.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s12896-017-0334-9) contains supplementary material, which is available to authorized users.</P>

발행연도

2017

발행기관

BioMed Central

라이선스

cc-by

ISSN

1472-6750

17

페이지

pp.15

주제어

Acidic pectinase; Bioscouring; Cotton fabric; Heterologous expression; High cell density fermentation

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1 2023-12-11

논문; 2017-02-16

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