BioChem - DOS

Bridging racemic lactate esters with stereoselective polylactic acid using commercial lipase catalysis

Green chemistry : an international journal and green chemistry resource : GC

Van Wouwe, Pieter; Dusselier, Michiel; Basiç , Aurelie; Sels, Bert F.

<P>A productive and enantioselective hydrolysis of racemic mixtures of lactate esters with commercial <I>Candida rugosa</I> lipase was performed. This step contributes to a novel envisioned route for stereoselective PLA production by combining recent chemocatalytic developments with this biocatalytic contribution, foreseeing two separate <SMALL>L</SMALL>- and <SMALL>D</SMALL>-lactate enantiomer streams. A study of the hydrolysis kinetics identified an unexpected rate determining step at the origin of an unprecedented ester reactivity order.</P><BR><BR><P>Graphic Abstract</P><P>Enantiopure <SMALL>D</SMALL>- and <SMALL>L</SMALL>-lactate fractions are synthesized in high productivity from racemic lactic acid ester feeds using <I>Candida rugosa</I> lipase.<BR><IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3gc41457d'><BR></P>

2013

The Royal Society of Chemistry

1463-9262

1463-9270

15

10

pp.2817-2824

10.1039/c3gc41457d

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART67058565