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Isolation and characterization of a novel rebaudioside M isomer from a bioconversion reaction of rebaudioside A and NMR comparison studies of rebaudioside M isolated from Stevia rebaudiana Bertoni and Stevia rebaudiana Morita

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논문

Isolation and characterization of a novel rebaudioside M isomer from a bioconversion reaction of rebaudioside A and NMR comparison studies of rebaudioside M isolated from Stevia rebaudiana Bertoni and Stevia rebaudiana Morita

학술지

Biomolecules

저자명

Prakash, Indra; Bunders, Cynthia; Devkota, Krishna P.; Charan, Romila D.; Ramirez, Catherine; Priedemann, Christopher; Markosyan, Avetik

초록

<P>A minor product, rebaudioside M2 (<B>2</B>), from the bioconversion reaction of rebaudioside A (<B>4</B>) to rebaudioside D (<B>3</B>), was isolated and the complete structure of the novel steviol glycoside was determined. Rebaudioside M2 (<B>2</B>) is considered an isomer of rebaudioside M (<B>1</B>) and contains a relatively rare 1<B>→</B>6 sugar linkage. It was isolated and characterized with NMR (<SUP>1</SUP>H, <SUP>13</SUP>C, COSY, HSQC-DEPT, HMBC, 1D-TOCSY, and NOESY) and mass spectral data. Additionally, we emphasize the importance of 1D and 2D NMR techniques when identifying complex steviol glycosides. Numerous NMR spectroscopy studies of rebaudioside M (<B>1</B>), rebaudioside D (<B>3</B>), and mixture of <B>1</B> and <B>3</B> led to the discovery that SG17 which was previously reported in literature, is a mixture of rebaudioside D (<B>3</B>), rebaudioside M (<B>1</B>), and possibly other related steviol glycosides.</P>

발행연도

2014

발행기관

MDPI

라이선스

cc-by

ISSN

2218-273x

4

2

페이지

pp.374-389

주제어

Stevia rebaudiana Bertoni; Stevia rebaudiana Morita; rebaudioside M; rebaudioside D; rebaudioside M2; bioconversion; steviol glycosides; structure characterization; nuclear magnetic resonance (NMR)

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논문; 2014-03-31

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