BioChem - DOS

Kinetic Modeling of fermentative production of 1,3-propanediol by Klebsiella pneumoniae HR526 with consideration of multiple product inhibitions

Applied biochemistry and biotechnology

He, Lu; Zhao, Xuebing; Cheng, Keke; Sun, Yan; Liu, Dehua

<P>During the fermentative production of 1, 3-propanediol (1,3-PD), the multiple product inhibitions cannot be negligible to accurately describe the kinetics of fermentation process. A kinetic model for fermentative production of 1,3-PD by Klebsiella pneumoniae HR526 with glycerol as carbon source under aerobic condition was proposed. The inhibitions of multiple products including 1,3-PD, 2, 3-butanediol (2,3-BD), acetate, and succinate were considered in the model. It was found that 1,3-PD, 2,3-BD, and acetate showed strong inhibitions to cell growth depending on their concentrations. The kinetic model was relatively accurate to predict the experimental data of batch, fed-batch, and continuous fermentations. The model thus can serve as a tool for further controlling and optimizing the fermentation process.</P>

2013

Springer-Verlag

0273-2289

1559-0291

169

1

pp.312-326

10.1007/s12010-012-9984-1

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART65452993