BioChem - DOS

Economic Considerations for Selecting an Amine Donor in Biocatalytic Transamination

Organic process research & development

Tufvesson, Pä r; Nordblad, Mathias; Krü hne, Ulrich; Schü rmann, Martin; Vogel, Andreas; Wohlgemuth, Roland; Woodley, John M.

<P>The industrial implementation of biocatalysis for production of pharma and fine chemicals has grown substantially over recent years. An upcoming application is that of chiral synthesis of optically pure amines, a technology known for many years but that is now seeing a renewed and wider interest in industry. The technology has been demonstrated in a few selected cases, but widespread implementation and for a broader range of target molecules requires a deeper understanding of the underlying thermodynamic as well as economic constraints for the different choices that can be made in designing the process, in particular the choice of amine donor. This paper discusses these constraints and demonstrates, through simple thermodynamic and economic models, the process targets that need to be set and achieved for a process dependent on allowed process costs and quality targets.</P><P><B>Graphic Abstract</B><BR><IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/oprdfk/2015/oprdfk.2015.19.issue-6/acs.oprd.5b00100/production/images/medium/op-2015-00100j_0001.gif'></P>

2015

American Chemical Society

1083-6160

1520-586x

19

6

pp.652-660

10.1021/acs.oprd.5b00100

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART72236421