초록
<P><B>Scope</B></P><P>The main aim of the present study is to study the effect of acute ketosis on parameters of appetite regulation in prediabetes.</P><P><B>Methods and results</B></P><P>This is a randomized controlled trial registered under ClinicalTrials.gov identifier NCT03889210. After an overnight fast, 18 adults with prediabetes are assigned to consume a ketone monoester (<SMALL>d</SMALL>‐β‐hydroxybutyrate‐(R)‐1,3 butanediol) drink and a placebo drink in cross‐over fashion. Blood samples are collected every 30 min, from baseline to 150 min. Paired <I>t</I> test is used to compare the total area under the curve (AUC) for the changes in parameters of appetite regulation (acylated ghrelin, peptide YY [PYY], and hunger) following both drinks. Significant elevation in blood β‐hydroxybutyrate from 0.2 to 3.5 mmol L<SUP>−1</SUP> (<I>p</I> < 0.001) is achieved within 30 min. Acute ketosis does not result in statistically significant differences in the AUCs for ghrelin, PYY, and hunger.</P><P><B>Conclusion</B></P><P>Acute ketosis consistently does not affect both objective and subjective parameters of appetite regulation in prediabetes.</P>