Directed evolution of Candida antarctica lipase B for kinetic resolution of profen esters

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바이오화학분류

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  1. 기타

논문

Directed evolution of Candida antarctica lipase B for kinetic resolution of profen esters

학술지

Catalysis communications

저자명

Qin, B.; Liang, P.; Jia, X.; Zhang, X.; Mu, M.; Wang, X.Y.; Ma, G.Z.; Jin, D.N.; You, S.

초록

The lipase B from Candida antarctica was subjected to directed evolution suggested by its structure. Mutants of the lipase show significantly increased activity and enantioselectivity toward profen esters compared to the wild type, especially for flurbiprofen ester (ee=93%, E=37) and ketoprofen ester (ee=99%, E>200).

발행연도

2013

발행기관

Elsevier

ISSN

1566-7367

권

페이지

pp.1-5

DOI

10.1016/j.catcom.2013.03.040

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