초록
<P><I>L</I>-ornithine and <I>L</I>-glutamine are amino acids used for ammonia and nitrogen transport in the human body. Novel biodegradable synthetic poly(lactic-<I>co</I>-glycolic acid) derivatives were synthesized via conjugation with <I>L</I>-ornithine or <I>L</I>-glutamine, which were selected due to their biological importance. <I>L</I>-ornithine or <I>L</I>-glutamine was integrated into a PLGA polymer with EDC coupling reactions as a structure developer after the synthesis of PLGA via the polycondensation and ring-opening polymerization of lactide and glycolide. The chemical, thermal, and degradation property–structure relationships of PLGA, PLGA-<I>L</I>-ornithine, and PLGA-<I>L</I>-glutamine were identified. The conjugation between PLGA and the amino acid was confirmed through observation of an increase in the number of carbonyl carbons in the range of 170–160 ppm in the <SUP>13</SUP>C NMR spectrum and the signal of the amide carbonyl vibration at about 1698 cm<SUP>−1</SUP> in the FTIR spectrum. The developed PLGA-<I>L</I>-ornithine and PLGA-<I>L</I>-glutamine derivatives were thermally stable and energetic materials. In addition, PLGA-<I>L</I>-ornithine and PLGA-<I>L</I>-glutamine, with their unique hydrophilic properties, had faster degradation times than PLGA in terms of surface-type erosion, which covers their requirements. <I>L</I>-ornithine- and <I>L</I>-glutamine-linked PLGAs are potential candidates for development into biodegradable PLGA-derived biopolymers that can be used as raw materials for biomaterials.</P>