초록
<P>The small amount of data regarding the antifungal activity of <I>Dittrichia viscosa</I> (L.) Greuter against dermatophytes, <I>Malassezia</I> spp. and <I>Aspergillus</I> spp., associated with the few comparative studies on the antimicrobial activity of methanolic, ethanolic, and butanolic extracts underpins the study herein presented. The total condensed tannin (TCT), phenol (TPC), flavonoid (TFC), and caffeoylquinic acid (CQC) content of methanol, butanol, and ethanol (80% and 100%) extracts of <I>D. viscosa</I> were assessed and their bactericidal and fungicidal activities were evaluated. The antibacterial, anti-<I>Candida</I> and anti-<I>Malassezia</I> activities were evaluated by using the disk diffusion method, whereas the anti-<I>Microsporum canis</I> and anti-<I>Aspergillus fumigatus</I> activities were assessed by studying the toxicity effect of the extracts on vegetative growth, sporulation and germination. The methanolic extract contained the highest TPC and CQC content. It contains several phytochemicals mainly caffeoylquinic acid derivatives as determined by liquid chromatography with photodiode array and electrospray ionisation mass spectrometric detection (LC/PDA/ESI-MS) analysis. All extracts showed an excellent inhibitory effect against bacteria and <I>Candida</I> spp., whereas methanolic extract exhibited the highest antifungal activities against <I>Malassezia</I> spp.<I>, M. canis</I> and <I>A. fumigatus</I> strains. The results clearly showed that all extracts, in particular the methanolic extract, might be excellent antimicrobial drugs for treating infections that are life threatening (i.e., <I>Malassezia</I>) or infections that require mandatory treatments (i.e., <I>M. canis</I> or <I>A. fumigatus</I>).</P>