Peroxygenase-Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol

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논문

Peroxygenase-Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol

학술지

Angewandte Chemie. international edition

저자명

Ni, Yan; Ferná ndez‐ Fueyo, Elena; Baraibar, Alvaro Gomez; Ullrich, René Hofrichter, Martin; Yanase, Hideshi; Alcalde, Miguel; van Berkel, Willem J. H.; Hollmann, Frank

초록

AbstractPeroxygenases catalyze a broad range of (stereo)selective oxyfunctionalization reactions. However, to access their full catalytic potential, peroxygenases need a balanced provision of hydrogen peroxide to achieve high catalytic activity while minimizing oxidative inactivation. Herein, we report an enzymatic cascade process that employs methanol as a sacrificial electron donor for the reductive activation of molecular oxygen. Full oxidation of methanol is achieved, generating three equivalents of hydrogen peroxide that can be used completely for the stereoselective hydroxylation of ethylbenzene as a model reaction. Overall we propose and demonstrate an atom‐efficient and easily applicable alternative to established hydrogen peroxide generation methods, which enables the efficient use of peroxygenases for oxyfunctionalization reactions.

발행연도

2016

발행기관

WILEY‐VCH Verlag

ISSN

1433-7851

ISSN

1521-3773

권

호

페이지

pp.798-801