BioChem - DOS

Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase

Journal of bioscience and bioengineering

Kojima, Y.; Wakita, J.; Inayoshi, Y.; Suzuki, R.; Yamada, Y.; Kaneoka, H.; Nishijima, K.i.; Iijima, S.

Human erythropoietin produced in the egg white of chimeric chicken contains N-glycan with lower amounts of terminal galactose and sialic acid; therefore, the chicken galactosyltransferase gene was introduced together with the human erythropoietin gene by a retroviral vector. We found that erythropoietin accumulated in the egg white was partially galactosylated.

2014

Society for Bioscience and Bioengineering, Japan ; Distributed outside Japan by Elsevier Science

1389-1723

1347-4421

117

6

pp.676-679

10.1016/j.jbiosc.2013.11.010

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART68991124

Transgenic chicken; Erythropoietin; Galactose; Galactosyltransferase; N-Glycan