More efficient redox biocatalysis by utilising 1,4-butanediol as a smart cosubstrate

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논문

More efficient redox biocatalysis by utilising 1,4-butanediol as a smart cosubstrate

학술지

Green chemistry : an international journal and green chemistry resource : GC

저자명

Kara, Selin; Spickermann, Dominik; Schrittwieser, Joerg H.; Leggewie, Christian; van Berkel, Willem J. H.; Arends, Isabel W. C. E.; Hollmann, Frank

초록

1,4-Butanediol is shown to be an efficient cosubstrate to promote NAD(P)H-dependent redox biocatalysis. The thermodynamically and kinetically inert lactone coproduct makes the regeneration reaction irreversible. Thereby not only the molar surplus of cosubstrate is dramatically reduced but also faster reaction rates are obtained. Graphic Abstract‘Smart cosubstrates’ yielding inert lactone coproducts enable efficient NAD(P)H-regeneration for bio-redox catalysis. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2gc36797a'>

발행연도

2013

발행기관

The Royal Society of Chemistry

ISSN

1463-9262

ISSN

1463-9270

권

호

페이지

pp.330-335