BioChem - DOS

Evaluation of the Enzymatic Reactive Distillation for the Production of Chiral Compounds

Chemie-Ingenieur-Technik

Wierschem, Matthias; Boll, Stefan; Lutze, Philip; Gó rak, Andrzej

<P><B>Abstract</B></P><P>In this work we investigated the feasibility of resolution and production of chiral compounds in an enzymatic reactive distillation column. Here, the transesterification of racemic 1&#8208;phenylethanol with isopropenyl acetate was chosen as the model system. Enzyme kinetics with the enzymatic catalyst <I>Candida antarctica</I> lipase B immobilized on polymer beads were investigated experimentally. Based on those, a detailed model of enzymatic reactive distillation was developed and a subsequent model&#8208;based process analysis showed the achievement of high conversion rates and a full separation of the reaction products.</P>

2016

WILEY&#x2010;VCH Verlag

0009-286x

1522-2640

88

1

pp.147-157

10.1002/cite.201500109

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART74849341

Biocatalysis; Process intensification; Process simulation