초록
<P>Two self-assembled barrel-rosette ion channels have been developed using bis(1,3-propanediol)-linked <I>m</I>-dipropynylbenzene-based molecules. The system with an additional amide arm acted as a better channel compared to that having an ester arm. The amide-linked channel displayed substantial channel activity and excellent chloride selectivity in the lipid bilayer membranes. Molecular dynamics simulation studies confirmed efficient hydrogen-bonded self-assembly of the amide-linked bis(1,3-propanediol)-based molecules in the lipid bilayer membrane and the detection of chloride recognition in the cavity.</P><P>Graphic Abstract</P><P>Two supramolecular barrel-rosette chloride channels are reported using bis(1,3-propanediol)-based molecules. The system with an additional amide tail showed superior transport activity than that with an ester tail due to better self-assembly.<BR/><IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=d2cc05155a'/><BR/></P>