BioChem - DOS

Creation of a Lipase Highly Selective for trans Fatty Acids by Protein Engineering

Angewandte Chemie. international edition

Brundiek, Henrike B.; Evitt, Andrew S.; Kourist, Robert; Bornscheuer, Uwe T.

<P><B>Sorting out</B>: Protein engineering of lipase CAL&#8208;A led to the discovery of mutants with excellent chemoselectivity for the removal of <I>trans</I> and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.</P>

2012

1433-7851

1521-3773

51

2

pp.412-414

10.1002/anie.201106126

http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=05787966&target=NART&cn=NART58386211

enzyme catalysis; fatty acids; high&#8208; throughput screening; lipases; protein engineering;