Positive effect of reduced aeration rate on secretion of alpha-amylase and neutral proteases during pressurised fermentation of thermophilic Bacillus caldolyticus

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논문

Positive effect of reduced aeration rate on secretion of alpha-amylase and neutral proteases during pressurised fermentation of thermophilic Bacillus caldolyticus

학술지

New biotechnology

저자명

Popovic, M.K.; Senz, M.; Bader, J.; Skelac, L.; Schilf, W.; Bajpai, R.

초록

The thermophilic microorganism Bacillus caldolyticus was incubated in laboratory scale stirred bioreactors under pressurised conditions at different aeration rates. Increased amounts of CO2/bicarbonate were solubilised under the chosen conditions. A reduction in aeration rate from 1vvm to 0.1vvm resulted in accumulation of CO2 and bicarbonate up to 126mgl-1 and 733mgl-1, respectively and also increased secretion of α-amylase and neutral proteases (increases of 123% and 52%, respectively). In this paper, the effect of reduced aeration rate on CO2/bicarbonate concentration and enzyme activities is presented. The selected fermentation conditions are closely related to those prevalent in large scale bioreactors and may offer the possibility of achieving high enzyme yields at reduced aeration costs on an industrial scale.

발행연도

2014

발행기관

Elsevier

ISSN

1871-6784

권

호

페이지

pp.141-149

DOI

10.1016/j.nbt.2013.10.007